Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1995-01-31
1996-07-02
Rollins, John W.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
424449, 424451, 424464, 514946, A61K 31165, A61K 970
Patent
active
055322786
ABSTRACT:
A method for treating urinary incontinence while avoiding concomitant liability of adverse effects associated with racemic oxybutynin is disclosed. The method comprises administering a therapeutically effective amount of (S)-oxybutynin or a pharmaceutically acceptable salt thereof, substantially free of its R enantiomer. Pharmaceutical compositions comprising (S)-oxybutynin and an acceptable carrier are also disclosed.
REFERENCES:
patent: 5236956 (1993-08-01), Sjogren et al.
patent: 5411740 (1995-05-01), Lee et al.
Lish et al. "Oxybutynin--A Musculotropic Antispasmodic Drug . . . " Arch. int. Pharmacodyn. 156, 456-488 (1965).
Hock "Clinical Evaulation of Oxybutynin Chloride" Current Therapeutic Research 9, 437-440 (1967).
Fredericks et al. "A Study of the Anticholinergic and Antispasmodic Activity of Oxybutynin . . . " Investigative Urology 12, 317-319 ((1975).
Nilvebrant et al. "Dicyclomine, Benzhexol and Oxybutynine Distinguish . . . " Europ. J. Pharmacol. 123, 133-143 (1986).
Tonini et al. "Depressant action of oxybutynin on the contractility . . . " J. Pharm. Pharmacol. 39, 103-107 (1986).
Kachur et al. "R and S Enantiomers of Oxybutynin: Pharmacological Effects . . . " J. Pharm. Exper. Ther. 247, 867-872 (1988).
Noronha-Blob et al. "Muscarinic Receptors: Relationships Among Phosphoinositide . . . " J. Pharm. Exper. Ther. 249, 843-851 (1989).
Noronha-Blob et al. "The Anticholinergic Activity of Agents Indicated for Urinary . . . " J. Pharm. Exper. Ther. 251, 586-593 (1989).
Peterson et al. "In Vivo Cystometrogram Studies in Urethane-Anesthetized and Conscious Guinea Pigs" J. Pharm. Methods 21, 231-241 (1989).
Guarneri et al. "Effects of Oxybutynin, Terodiline, and Nifedipine . . . " Pharm. Research 24, 263-272 (1991).
Noronha-Blob et al. "Enantiomers of Oxybutynin: In Vitro Pharmacological Characterization . . . " J. Pharm. Exp. Ther. 256, 562-567 (1990).
Lowe et al. "Effect of extracellular CA.sup.2+ on cholinergic, KCl and phorbol ester-mediated . . . " Eur. J. Pharm. 195, 273-279 (1991).
Massad et al. "The Pharmacokinetics of Intravesical and Oral Oxybutynin Chloride" J. Urology 148, 595-597 (1992).
Angelico et al. "In Vivo Effects of Different Antispasmodic Drugs on the Rat Bladder Contractions" J. Pharm. Methods 27, 33-39 (1992).
Guarneri et al. "Effects of Drugs Used in the Therapy of Detrusor Hyperactivity . . . " Pharm. Research 27, 173-187 (1993).
Aberg Gunnar
McCullough John R.
Rollins John W.
Sepracor Inc.
LandOfFree
Methods and compositions for treating urinary incontinence using does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods and compositions for treating urinary incontinence using, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and compositions for treating urinary incontinence using will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1506852