Low diol polyalkylene oxide biologically active proteinaceous su

Details Low diol polyalkylene oxide biologically active proteinaceous su Low diol polyalkylene oxide biologically active proteinaceous su

1994-05-19

1996-07-02

Rollins, John W.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Stablizing an enzyme by forming a mixture, an adduct or a...

C12N 996

Patent

active

055321500

ABSTRACT:
Disclosed are pharmaceutical compositions containing low diol polyethylene glycol, covalently attached to superoxide and dismutase process of making the compositions. Also disclosed is a method of treatment of disease processes associated with the adverse effects on tissue of superoxide anions, such as ischemic events, reperfusion injury, trauma and inflammation.

REFERENCES:
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Abuchowski, A. et al, Cancer Biochem. Biophysics, 1984, vol. 7, pp. 175-186.
Abuchowski, A., Doctor of Philosophy Thesis, "Effects of Covalent Attachment of Polyethylene Glycol on Bovine Serum Albumin and Bovine Liver Catalase", Rutgers University, New Brunswick, NJ, USA, Oct. 1975.
Veronese, F. M. et al, J. of Pharm & Pharmacol., 35, pp. 757-758 (1983).
Veronese, F. M. et al, J. of Controlled Release, 10, pp. 145-154 (1989).
Zalipsky, S. et al, Eur. Polym. J., 12, pp. 1177-1183 (1983).
Kazo, G. M., Master of Science in Biochemistry Thesis, "Modification of Proteins with Activated Polyethylene Glycols", Rutgers University, New Brunswick, NJ, Oct. 1985.

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