Process and intermediate products for the production of 5-oxaspi

Details Process and intermediate products for the production of 5-oxaspi Process and intermediate products for the production of 5-oxaspi

1995-04-05

1996-01-23

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549323, 549324, 549510, 558384, 558451, C07D30794, C07D30726, C07C25500

Patent

active

054866227

ABSTRACT:
5-Oxaspiro[2.4]heptan-6-one: ##STR1## is obtained from [3-(hydroxymethyl)oxetan-3-yl]acetonitrile by reaction with hydrogen bromide and then cyclizing the intermediate product 4,4-bis(bromomethyl)dihydro-2-furanone with zinc. 5-Oxaspiro[2.4]heptan-6-one is an intermediate product for the production of leukotriene antagonists.

REFERENCES:
F. Govaert and P. Cornand, Meded. K. Vlaam, Acad. Wet., Lett. Schone Kunsten Belg., Kl. Wet., (16), (1954), 1-13.
D. Wendisch, Methoden Org. Chem. [Methods of Org. Chem.] (Houben-Weyl), 4th Edition, vol. IV/3, pp. 32-42.

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