Intermediates for preparing antifolate compounds

Details Intermediates for preparing antifolate compounds Intermediates for preparing antifolate compounds

1995-05-30

1996-01-23

Datlow, Philip I.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546212, 546214, 546221, 544279, C07D21178, C07D40506, C07D40906

Patent

active

054866146

ABSTRACT:
This invention relates to intermediates, and processes thereto, for the preparation of tetrahydropyrido[2,3-d]pyrimidines which are useful for the treatment of susceptable neoplasms. The intermediates have the following formula II; ##STR1## wherein the R, R.sup.1 and A groups are as defined in the specification.

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Barnett, et al., Tetrahedron Letters, 30:6291-6294 (1989).
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Szcycinski, B., Chem. Abs., 90:168638w (1978).
Snider, T. E., et al., Org. Prep. and Procedures Int., 4(5):237-245 (1972).
DeGraw, J., et al., Canadian J. Chem., 41:3137-3139 (1963).

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