Process for the preparation of an intermediate of a benzo[a]quin

Details Process for the preparation of an intermediate of a benzo[a]quin Process for the preparation of an intermediate of a benzo[a]quin

1995-05-30

1996-10-01

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D45506

Patent

active

055612334

ABSTRACT:
The invention is concerned with a process for the preparation of a benzo[a]quinolizinone derivative of the formula ##STR1## by reacting a compound of the formula ##STR2## wherein X is halogen and Ph is phenyl, with carbon monoxide in the presence of a carbonylation catalyst and in the presence of (S)-3-ethoxypyrrolidine or a lower alkanol or water; where a lower alkyl ester of the 10-chloro-6,7-dihydro-4 -oxo-3-phenyl-4H-benzo[a]quinolizine-1-carboxylic acid has been obtained, converting this into the corresponding free acid; and, where the 10-chloro-6,7-dihydro-4-oxo-3-phenyl-4H-benzo[a]quinolizine-1-carboxylic acid has been obtained, reacting a reactive derivative thereof with (S)-3-ethoxypyrrolidine. The compound of formula I is useful for the treatment or prophylaxis of sleep disorders.

REFERENCES:
patent: 4735940 (1988-04-01), Fischer et al.
patent: 4889848 (1989-12-01), Fischer et al.
patent: 5026892 (1991-06-01), Kirchhoff
patent: 5036066 (1991-07-01), Fischer et al.
patent: 5281711 (1994-01-01), Scherschlict et al.
patent: 5321021 (1994-06-01), Fischer et al.
patent: 5326769 (1994-07-01), Scherschlict et al.
Spurr, PR, Tetrahedron Lett. (1995). 36(16) 2745-8.
Fischer, et al. Helvetica Chimica Acta, vol. 73, pp. 763-781 (1990).
Larsen, et al. J. Org. Chem. vol. 56, pp. 6034-6038 (1991).
Bhat, et al. Synthetic Communications, vol. 15(7) pp. 587-598 (1985).
Tamazawa et al.,J. Med. Chem. vol. 29, pp. 2504-2511 (1986).

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