Transcription factor for regulation of the development of skin a

Details Transcription factor for regulation of the development of skin a Transcription factor for regulation of the development of skin a

1995-07-20

1996-10-01

Elliott, George C.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C07K 1400

Patent

active

055612245

ABSTRACT:
A gene encoding for alternative forms of a POU domain transcription factor is disclosed. The first polypeptide form of the transcription factor includes a transferable region which inhibits DNA binding by itself and other transcription factors. The second polypeptide form serves to activate expression of a gene typical for terminal differentiation of skin. Fusion proteins wherein the inhibitory region of the first form of the gene is coupled to, and inhibits the function of, other transcription factors are also disclosed.

REFERENCES:
Masafumi Tanaka, et al; Activation of the U2 snRNA promoter by the octamer . . . Genes and Development; 2:1764-1778, 1988.
Colin Fletcher, et al.; Purification and Characterization of OTF-1, . . . Cell, vol. 51, 773-781, Dec. 4, 1987.
A. Goldsborougm et al Nucleic Acids Res. (1990) 18(6): 1634 (1 page article).
A. Goldsborougm et al Nucleic Acids Res. (1993) 21(1): 127-134.

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