Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-10-03
1996-10-01
Gupta, Yogendra N.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514 46, 514261, 514303, 544264, 546118, A61K 3152, C07D47334
Patent
active
055611346
ABSTRACT:
Compounds of the Formula ##STR1## wherein: K is N or N.fwdarw.O; Q is CH.sub.2 or O; T is ##STR2## or R.sub.3 O--CH.sub.2 ; X is a straight or branched chain alkylene, cycloalkylene or cycloalkenylene group, each of which is optionally substituted by at least one CH.sub.3, CH.sub.3 CH.sub.2, Cl, F, CF.sub.3 or CH.sub.3 O; Y is NR.sub.4, O or S; a=0 or 1; Z is of the formula ##STR3## Z.sub.1 is N, CR.sub.5, (CH).sub.m --CR.sub.5 or (CH).sub.m --N, m being 1 or 2; Z.sub.2 is N, NR.sub.6, O or S, n being 0 or 1; R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and R.sub.6 are independently H, alkyl, aryl or heterocyclyl; R.sub.a and R.sub.b are independently H, OH, alkyl, hydroxyalkyl, alkyl mercaptyl, thioalkyl, alkoxy, alkyoxyalkyl, amino, alkyl amino, carboxyl, acyl, halogen, carbamoyl, alkyl carbamoyl, aryl or heterocyclyl; and R' and R" are independently hydrogen, alkyl, aralkyl, carbamoyl, alkyl carbamoyl, dialkylcarbamoyl, acyl, alkoxycarbonyl aralkoxycarbonyl, aryloxycarbonyl, or R' and R" together may form ##STR4## where R.sub.c is hydrogen or alkyl, ##STR5## where R.sub.d and R.sub.e are independently hydrogen, alkyl, or together with the carbon atom to which they are attached may form a 1,1-cycloalkyl group; provided that when X is straight chain alkylene and Q is oxygen, then Z represents a heterocyclyl including at least two heteroatoms, which are adenosine agonists useful as antihypertensive, cardioprotective, antiischemic, and antilipolytic agents, pharmaceutical compositions including such compounds, and their use in treating hypertension, myocardial ischemia, ameliorating ischemic injury and myocardial infarct size consequent to myocardial ischemia, hyperlipidemia and hypercholesterolemia are claimed.
REFERENCES:
patent: 3502649 (1970-03-01), Thiel et al.
patent: 3864483 (1975-02-01), Stein et al.
patent: 3914415 (1975-10-01), Stein et al.
patent: 3931401 (1976-06-01), Prasad et al.
patent: 4167565 (1979-09-01), Stein et al.
patent: 4340730 (1982-07-01), Henderson et al.
patent: 4501735 (1985-02-01), Trivedi et al.
patent: 4593019 (1986-06-01), Bristol et al.
patent: 4600707 (1986-07-01), Patt
patent: 4636493 (1987-01-01), Patt
patent: 4657897 (1987-04-01), Moos et al.
patent: 4657898 (1987-04-01), Bristol et al.
patent: 4663313 (1987-05-01), Bristol et al.
patent: 4683223 (1987-07-01), Trivedi
patent: 4738954 (1988-04-01), Hamllton et al.
patent: 4843066 (1989-06-01), Yamada et al.
patent: 4853386 (1989-08-01), Friebe et al.
patent: 4954504 (1990-09-01), Chen et al.
patent: 4968697 (1990-11-01), Hutchison
patent: 4977144 (1990-12-01), Fujimoto et al.
patent: 5032583 (1991-07-01), Evans
patent: 5043325 (1991-08-01), Olsson et al.
patent: 5063233 (1991-11-01), Chen et al.
patent: 5310731 (1994-05-01), Olsson et al.
Nuclcosides & Nucleotides, 10(1-3), 393-396 (1991), Baxter et al., Synthesis and Biological Activity of Carbocyclic Clitocine.
J. Med. Chem. 1985, 28, pp. 471-477, Houston et al., Potential Inhibitors of S-Adenosylmothionine-Dependent Methyltransferases. 9.
Nucleosides & Nucleotides, 10(1-3), 543-545 (1991), Franchetti et al., Synthesis of 3-Doazaclitocine[2-Amino-3-Nitro-4-(Beta-D-.
J. Med. Chem., 1976, vol. 19, No. 10, pp. 1180-1186, Prasad et al., Modification of the 5' Position of Purine Nucleosides. 1. Synthesis and Biological.
Nucleosides & Nucleotides 4(5), 625-639 (1985), Cristalli et al., Adenosine and 2-chloroadenosine Deaza Analogs as Adenosine.
Br. J. Pharmacol., vol. 109, 693 (1993), Gurden et al., Functional characterization of three adenosine receptor types.
Fink Cynthia A.
Myers Michael R.
Spada Alfred P.
Darkes Paul R.
Gupta Yogendra N.
Rhone-Poulenc Rorer Pharmaceuticals Inc.
Savitzky Martin F.
LandOfFree
Compounds having antihypertensive, cardioprotective, anti-ischem does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Compounds having antihypertensive, cardioprotective, anti-ischem, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compounds having antihypertensive, cardioprotective, anti-ischem will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1502123