Estradiol derivative and growth inhibiting composition thereof

Details Estradiol derivative and growth inhibiting composition thereof Estradiol derivative and growth inhibiting composition thereof

1995-03-22

1996-10-01

Prior, Kimberly J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

552613, 552614, 552618, 552626, A61K 31565, C07J 100

Patent

active

055611257

ABSTRACT:
Estradiol derivatives of the formula: ##STR1## wherein R.sup.1 is C.sub.1-4 alky or C.sub.1-4 alkoxy; R.sup.2 is acyl or benzyl; m is an integer of 1 to 3; n is an integer of 1 to 3; and X is hydroxy or halogen are useful as tumor growth inhibiting agents.

REFERENCES:
patent: 4261910 (1981-04-01), Asano et al.
patent: 4332797 (1982-06-01), Asano et al.
patent: 5354745 (1994-10-01), Tamura et al.
Pharmazie 38 (1983), H. 7 pp. 445-448 Mohsen et al Steroidal Derivatives "Synthesis and in vitro Anabolic and Catabolic Properties of a New Group of Steroidal Alkylating Agents".
J. Steroid Biochem. vol. 29, No. 6, pp. 657-664, 1988 Qian et al "Synthesis and Biological Activity of 17.beta.-Substituted Estradiol".
Montforts, et al, Angew. Chem. Int. Ed. Engl., 31 (12) (1992), pp. 1592-1594.
Omar, et al, Pharmazie, 35 (1980) pp. 445-448.

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