Method of treating proliferative skin disorders with 19-nor-vita

Details Method of treating proliferative skin disorders with 19-nor-vita Method of treating proliferative skin disorders with 19-nor-vita

1995-05-16

1996-10-01

Prior, Kimberly J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

9,10-seco- cyclopentanohydrophenanthrene ring system doai

552653, A61K 3159, C07C40100

Patent

active

055611230

ABSTRACT:
This invention provides a novel class of vitamin D-related compounds, namely the 1.alpha.-hydroxy-19-nor-vitamin D analogs, as well as a general method for their chemical synthesis. The compounds exhibit pronounced activity in arresting the proliferation of undifferentiated cells, including malignant cells, and in inducing their differentiation, and thus represent novel therapeutic agents for the treatment of malignant and other diseases characterized by the proliferative growth of undifferentiated cells. Formulations for therapeutic use and treatment methods are also provided. The 19-nor analogs useful herein are of the general formula ##STR1## where X.sup.1 and X.sup.2 each hydrogen, acyl, alkylisilyl or alkoxyalkyl, and where R is any of the typical side chains known for vitamin D type compounds.

REFERENCES:
patent: 4410515 (1983-10-01), Holick et al.
patent: 4448726 (1984-05-01), DeLuca et al.
patent: 4769181 (1988-09-01), DeLuca et al.
patent: 5086191 (1992-02-01), Deluca et al.
patent: 5185150 (1993-02-01), DeLuca et al.
patent: 5246925 (1993-09-01), DeLuca et al.
patent: 5281731 (1994-01-01), DeLuca et al.
patent: 5321018 (1994-06-01), DeLuca et al.
patent: 5342975 (1994-08-01), DeLuca et al.
patent: 5403940 (1995-04-01), Valle's et al.
patent: 5428029 (1995-06-01), Doran et al.
patent: 5449668 (1995-09-01), Sestelo et al.
patent: 5451574 (1995-09-01), Baggiolini et al.
Chemical Abstracts (110:19004r) 1989.
Lythgoe et al "Calciferol And Its Relatives. Part 22. A Direct Total Synthesis of Vitamin D3", Journal of The Chemical Society, Perkin Transactions I, vol. 6, 1978, pp. 590-595.

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