Lipoxin compounds

Details Lipoxin compounds Lipoxin compounds

1995-05-31

1997-07-15

Geist, Gary

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560 19, 560103, 560187, 562587, C07C32108, C07C 6966, C07C 59105

Patent

active

056485123

ABSTRACT:
Compounds having the active site of natural lipoxins, but a longer tissue hlf-life are disclosed. These small molecules are useful for treating vasoconstrictive, inflammatory, myeloid suppressive, cardiovascular, and gastrointestinal diseases.

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patent: 5049681 (1991-09-01), Sato
patent: 5079261 (1992-01-01), Serhan et al.
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Lee, et al., "Inhibition of Leukotriene B.sub.4 -Induced Neutrophil Migration by Lipoxin A.sub.4 : Structure-Function Relationships", Biochemical and Biophysical Research Communications, (1991), vol. 180, No. 3, pp. 1416-1421.
Mizukami, et al., ".omega.-Hydroxylation of Lipoxin B.sub.4 by Human Neutrophil Microsomes: Identification of .omega.-hydroxy Metabolite of Lipoxin B.sub.4 and Catalysis by Leukotriene B.sub.4 .omega.-hydroxylase (cytochrome P-450LTB.omega.)", Biochimica et Biophysica Acta (1993), No. 1168, pp. 87-93.
Nicolaou, et al., "Lipoxins and Related Eicosanoids: Biosynthesis Biological Properties, and Chemical Synthesis", Angew, Chem. Int. Ed. Engl., (1991), vol. 30, pp. 1100-1116.
Nicolaou, et al., "Identification of a Novel 7-cis-11-trans-lipoxin A.sub.4 Generated by Human Neutrophils: Total Synthesis, Spasmogenic Activities and Comparison with Other Geometric Isomers of Lipoxin A.sub.4 and B.sub.4 ", Biochimica et Biophysica Acta, (1989), No. 1003, pp. 44-53.
Nicolaou, et al., "Total Synthesis of Novel Geometric Isomers of Lipoxin A.sub.4 and Lipoxin B.sub.4 ", Reprint from The Journal of Organic Chemistry (1989), vol. 54, No. 23, pp. 5527-5535.
Nigam, et al., "Lipoxin A.sub.4 and Lioxin B.sub.4 Stimulate the Release but Not the Oxygenation of Arachidonic Acid in Human Neutrophils: Dissociation between Lipid Remodeling and Adhesion", Journal of Cellular Physiology, (1990), vol. 143, pp. 512-523.
Popov, et al., "Effect of Lipoxin B on Cology-Forming Ability of Human Peripheral Blood Mononuclears in a Diffusion Chamber", Translated from Byulleten' Eksperimental' noi Biologii i Medisiny, (1989), vol. 107, No. 1, pp. 80-83.
Serhan, "Lipoxins: Eicosanoids Carrying Intra-and Intercellular Messages", Journal of Bioenergetics and Biomembranes, (1991), vol. 23, No. 1, pp. 105-122.
International Search Report (Form PCT/ISA/220) in PCT/US94/95722 which was mailed Oct. 10, 1994.

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