Process for preparation of hydroxyaryldialkylcarbinols

Details Process for preparation of hydroxyaryldialkylcarbinols Process for preparation of hydroxyaryldialkylcarbinols

1983-02-22

1984-07-17

Lone, Werren B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

568811, C07C 3910

Patent

active

044608004

ABSTRACT:
The preparation of hydroxyaryldialkylcarbinols by the reaction of hydroxyaryl alkyl ketones or alkyl hydroxyarenecarboxylates with Grignard reagents in a mixed ether-aromatic hydrocarbon solvent is frequently difficult on a large-scale basis because of formation of a voluminous precipitate of mixed magnesium salt. In an improvement in this process, a solution of the ketone or ester in an ether is added to the solution of the Grignard reagent.

REFERENCES:
patent: 4239918 (1980-12-01), Keeley
"The Synthesis of N-Methyl-3-Isopropyl-4-Dimethylaminophenyl Carbamate and some Related Derivatives"; H. Gilman, S. Avakian, R. Benkeser, H. Broadbent, R. Clark, G. Karmas, F. Marshall, S. Massie, D. Shirley, and L. Woods; J. Org. Chem., 19, pp. 1067,1071 (1954).
Organic Syntheses, Coll. vol. I, 186-187 (1941).

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