Derivatives of antibiotic substance milbemycin and processes the

Details Derivatives of antibiotic substance milbemycin and processes the Derivatives of antibiotic substance milbemycin and processes the

1977-04-11

1978-06-06

Trousof, Natalie

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

26034341, 424279, 424274, C07D49322

Patent

active

040936295

ABSTRACT:
Derivatives of the antibiotic substance milbemycin, also identified as B-41 are prepared. Milbemycin is brominated, acetylated and hydrolized in order to prepare the 13-hydroxy derivative thereof. The novel derivatives have antiparasitic activity.

REFERENCES:
patent: 3950360 (1976-04-01), Aoki et al.
patent: 3984564 (1976-10-01), Aoki et al.
Wagner & Zook, Synthetic Organic Chemistry, John Wiley & Sons, Inc., New York 1953, pp. 484, 169.
House, Modern Synthetic Reactions, W. A. Benjamin, Inc., Menlo Park, Calif., 1972, p. 481.
Mishima et al., Tetrahedron Letters, pp. 711-714, 1975.
Derwent Abstracts, 76268w/46, to Sankyo Co., Ltd., Abstract Japanese Patent Application 29742/75.

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