Process for preparing heterocyclicalkylthioalkyl-N-cyanoguanidin

Details Process for preparing heterocyclicalkylthioalkyl-N-cyanoguanidin Process for preparing heterocyclicalkylthioalkyl-N-cyanoguanidin

1976-11-15

1978-06-06

Rotman, Alan L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2602948G, 260302R, 260302A, 260302D, 260307H, 260308R, 548342, C07D21344, C07D23330

Patent

active

040936210

ABSTRACT:
Process for preparing heterocyclicalkylthioalkyl-N-cyanoguanidines and thioureas by treating a heterocyclicalkyl derivative with a mercaptoalkyl-N-cyanoguanidine or thiourea. Two specific products are N-cyano-N'-methyl-N"-[2-((5-methyl-4-imidazolyl)methylthio)ethyl]guanidine and N-methyl-N'-[2-((5-methyl-4-imidazolyl)methylthio)ethyl]thiourea, both useful as histamine H.sub.2 -antagonists.

REFERENCES:
patent: 3905984 (1975-09-01), Durant et al.

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