Process for purifying coagulation factor VIII using DEAE-crossli

Details Process for purifying coagulation factor VIII using DEAE-crossli Process for purifying coagulation factor VIII using DEAE-crossli

1977-04-01

1978-06-06

Schain, Howard E.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424101, 424177, C07G 700

Patent

active

040936082

ABSTRACT:
A process for purifying coagulation factor VIII which comprises contacting a plasma or a plasma fraction containing prothrombin complex and coagulation factor VIII (antihemophilic factor A) with diethylaminoethyl-crosslinked dextran to adsorb and remove the prothrombin complex from said plasma or plasma fraction. Coagulation factor VIII thus obtained can be administered to control the bleeding in hemophilia A patients.

REFERENCES:
patent: 3717708 (1973-02-01), Wada et al.
patent: 3803115 (1974-04-01), Fekete et al.
patent: 3920625 (1975-11-01), Andersson et al.
New England J. of Med. 280, 581-586 (1969), Hoag et al.
Proc. Soc. Expgl. Biol. Med. 116(1), 120-122 (1964), Lewis.
Chem. Abstracts, vol. 63, 1965, 4099d-e, Michael et al.
British J. Haematology, 1963, 9, pp. 236-244, Michael et al.
Pathol.-Biol. 1975, 23, Suppl, 11-16 (Mazurier et al.).

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