Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1996-06-21
1997-07-15
Elliott, George C.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435419, 4353201, 435348, 435325, 435358, 435367, 435369, 536 235, C12N 1500, C12N 1585, C12N 1563, C12N 1511
Patent
active
056482396
ABSTRACT:
The present invention provides a polynucleotide (ipka) which identifies and encodes a novel human cAMP-dependent protein kinase A inhibitor homolog (IPKA). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding IPKA.
REFERENCES:
Olsen SR, et al. "Isolation and characterization of cDNA clones for an inhibitor protein of cAMP-dependent protein kinases." JBC 266 (17): 11158-11162 1991.
Baude et al., Evidence for the Importance of Hydrophobic Residues in the Interactions between the cAMP-dependent Protein Kinase Catalytic Subunit and the Protein Kinase Inhibitors, J. Biol. Chem., 1996, 269:18128-18133.
Drumm et al., Molecular Biology of Cystic Fibrosis, Mol. Genet Med., 1993, 3:33-68.
Marchetto et al., Cloning and sequencing of the cDNA encoding the avian kidney cAMP-dependent protein kinase inhibitor protein, Gene, 1995, 158:303-304.
Wang et al., Specific Processing of Native and Phosphorylated .tau. Protein by Proteases, Biochem. Biophys. Res. Com., 219:591-597.
Wen et al., The Expression and Intracellular Distribution of the Heat-stable Protein Kinase Inhibitor Is Cell Cycle Regulated, J. Biol. Chem., 1995 270(5):2041-2046.
Au-Young Janice
Hawkins Phillip R.
Hillman Jennifer L.
Billings Lucy J.
Elliott George C.
Incyte Pharmaceuticals Inc.
Nelson Amy J.
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