Suppression of reaginic antibodies to drugs employing polyvinyl

Details Suppression of reaginic antibodies to drugs employing polyvinyl Suppression of reaginic antibodies to drugs employing polyvinyl

1979-02-27

1981-10-20

Fagelson, Anna P.

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

Polymer from ethylenic monomers only

2602391, 424 9, 424 80, 424271, A61K 3174, A61K 3143

Patent

active

042960975

ABSTRACT:
This invention relates to tolerogenic conjugates, suitable for use in suppressing the formation of reaginic antibodies in a host, of haptenic determinants, in particular the benzylpenicilloyl (BPO) group and 2,4-dinitrophenyl (DNP) group, with water-soluble, nonimmunogenic polymers, i.e. polyvinyl alcohols (PVA). The invention also comprises a method for the preparation of the conjugate and a method of suppressing the formation of these antibodies in a mammal sensitive to penicillin.

REFERENCES:
patent: 2155658 (1939-04-01), Herrmann
Sehon, J. Allergy Clin. Immunol. vol. 61, Mar. 1978, p. 179, Ab. No. 167.
Chiorazzi, Fed. Proc. vol. 35, No. 3, 1976, Ab. No. 1258.
Pan, Fed. Proc. vol. 35, No. 3, 1976, Ab. No. 1255.
Chiller, Fed. Proc. vol. 35, No. 3 1976, Ab. No. 1259.

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