Reducing pesticide resistance

Details Reducing pesticide resistance Reducing pesticide resistance

1995-03-15

1997-07-15

Levy, Neil S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Biocides; animal or insect repellents or attractants

514 89, 514 65, 514478, 514305, A01N 2500

Patent

active

056480857

ABSTRACT:
Pest populations that have developed pesticide resistance can be treated and killed with an inhibitor for ATP-dependent 150-180 kDa membrane P-glycoprotein as a pretreatment or simultaneously with application of a pesticide at doses which, by themselves, are not toxic to the pests.

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"Disruption Of The Mouse mdrla P-Glycoprotein Gene Leads To A Deficiency In The Blood-Brain Barrier And To Increased Sensitivity To Drugs", A.H. Schinkel et al., Cell, vol. 77, pp. 491-502, May 20, 1994, Copyright .COPYRGT.1994 by Cell Press.
"Insect Resistance To Insecticides: Mechanisms And Diagnosis", N.R. Price, Comp. Biochem. Physiol., vol. 100C, No. 3, pp. 319-326, 1991.
Albert Selective Toxicity pp. 3, 13 1973.
Sarkadi et al.; Expression Of Human Multidrug Resistance--in J. Biological Chemistry vol. 267 #7 Mar. 5, 1992 pp. 4854-4858.
Somani et al Drug Interaction for Plasma Protein Binding--in J. Clin. Pharm. Therapy & Toxicology vol. 25 #8--1987 pp. 412-416.

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