Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – Molecular bilayer structure
Patent
1974-01-04
1976-12-28
Padgett, Benjamin R.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
Molecular bilayer structure
23230B, 232303, 23253R, 250303, 250361R, 250362, 250363R, 424 15, 424 12, G01N 3300, G01T 116, A61K 3900, G01N 3316
Patent
active
040002527
ABSTRACT:
A means and method of radioimmunoassay is disclosed whereby an insolubilized or solid phosphor and binding agent such as an antibody are associated by chemical or physical means to provide a solid scintillating immunoadsorbent cell. This cell is capable of selectively binding or retaining radioactive or labeled antigens and transmitting radioactive energy to a phosphor or photon emitting substance. The luminescence emitted by the phosphor is measured by a scintillator counter and is directly proportional to the radioactive energy released by the labeled antigen bound to the antibody. Upon completion of the measurement the labeled antigens are separated from the antibody and removed from the cell which may now be used for additional analysis. A convenient means for obtaining a solid phosphor and/or binding agent is to combine them by physical or chemical means or to shield one from the other by a separating barrier. In addition the phosphor and/or the binding agent can be attached to an insoluble support medium which can take various structured shapes and forms.
REFERENCES:
patent: 3206602 (1965-09-01), Eberle
patent: 3404270 (1968-10-01), Ross
patent: 3573220 (1971-03-01), Benson
patent: 3758412 (1973-09-01), Grum et al.
patent: 3798448 (1974-03-01), Menefee et al.
Ayad, Laboratory Practice, vol. 21, No. 10, Oct. 1972.
Bojanowski Richard F.
Nucker Christine M.
Padgett Benjamin R.
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