Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1978-09-13
1980-06-24
Rollins, Alton D.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
260239E, 2602433, 2602444, 2602454, 2602455, 544 585, 544 82, 544130, 544132, 544366, 546191, 546210, 548262, A61K 3141, A61K 31535, C07D24908, C07D41306
Patent
active
042095158
ABSTRACT:
The present invention relates to new triazole derivatives of the formula ##STR1## wherein R.sub.1 represents hydrogen, lower alkyl, optionally esterified or etherified hydroxymethyl, formyl, optionally functionally modified carboxy, or optionally mono- or disubstituted aminomethyl, R.sub.2 represents lower alkyl, and R.sub.3 represents hydrogen or lower alkyl, whereby R.sub.2 and R.sub.3 as lower alkyl can be bound directly, or in .beta.- or .gamma.-position also by way of oxygen, sulphur or the imino radical or a lower alkylimino radical, and the rings A and B independently of each other can be unsubstituted or substituted, and to their addition salts with inorganic and organic acids, in particular the pharmaceutically acceptable acid addition salts. These new compounds possess valuable pharmacological properties. In particular they have an anticonvulsive activity and are useful for the treatment of epilepsy and of conditions of tension and of agitation. Specific embodiments are the 1-[2-(o-chlorobenzoyl)-4-chlorophenyl]-5-(morpholinomethyl)-1H-1,2,4-triaz ole-3-carboxamide and the N,N-dimethyl-1-[2-(o-fluorobenzoyl)-4-chlorophenyl]-5-[(dimethylamino)-met hyl]-1H-1,2,4-triazole-3-carboxamide.
REFERENCES:
patent: 3784556 (1974-01-01), Gagneux et al.
patent: 3856792 (1974-12-01), Hester
patent: 3862171 (1975-01-01), Gagneux et al.
patent: 3870714 (1975-03-01), Gagneux et al.
patent: 3878205 (1975-04-01), Gagneux et al.
patent: 3907821 (1975-09-01), Gall
Heckendorn Roland
Meier Rene
Ciba-Geigy Corporation
Maitner John J.
Rollins Alton D.
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