Process for producing 4-acetoxyacetanilide

Details Process for producing 4-acetoxyacetanilide Process for producing 4-acetoxyacetanilide

1984-07-03

1985-12-24

Trousof, Natalie

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

564223, C07C10346, C07C10338

Patent

active

045607893

ABSTRACT:
4-Acetoxyacetanilide is produced by subjecting phenyl acetate to a Fries rearrangement or phenol and an acetylating agent to a Friedel-Crafts acetylation to form 4-hydroxyacetophenone which is then reacted with hydroxylamine or a hydroxylamine salt to form 4-hydroxyacetophenone oxime. The oxime is then subjected to a Beckmann rearrangement and accompanying acetylation with acetic anhydride to form the 4-acetoxyacetanilide.

REFERENCES:
patent: 2833825 (1978-05-01), Lewis
patent: 4347372 (1982-08-01), Fory et al.
patent: 4524217 (1985-06-01), Davenport et al.
Auwers et al, Chemishe Berichte, 58, 36-51, (Germany 1925).
Ganboa et al, Synthetic Communications, 13 (11), 941-944, (1983).
Pearson et al, J. Amer. Chem. Soc., 75, 5905-5908, (1953).
Simons et al, J. Amer. Chem. Soc., 62, 485 and 486, (1940); 61, 1795 and 1796 (1939).
Dann and Mylius, Annalen der Chemie, 587 Band, 1-15, (W. Germany, 1954).
J. Pharmaceutical Sciences, vol. 59, No. 12, pp. 1738-1741; Rattie et al.
Fieser and Fieser, Organic Chemistry, 3rd Ed., Reinhold Publ. Corp., New York, 1956, pp. 211-212, 627.

Affiliated with

Also associated with

Rating

Process for producing 4-acetoxyacetanilide does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for producing 4-acetoxyacetanilide, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for producing 4-acetoxyacetanilide will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1480270