Tricyclic antihistamines

Details Tricyclic antihistamines Tricyclic antihistamines

1984-02-08

1985-12-24

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514248, 514250, 514267, 514322, 514323, 514359, 514393, 514406, 514411, 544183, 544234, 544249, 544344, 546199, 546200, 548257, 548259, 548260, 548261, 548323, 548369, 548427, A61K 3153, C07D25308

Patent

active

045606889

ABSTRACT:
Antihistamines of the formula ##STR1## wherein ##STR2## is a 5 or 6 membered ring which is phenyl or heterocyclic; ##STR3## is a six membered ring which is 2,3, or 4 pyridyl or is phenyl or substituted phenyl, with the proviso that is ##STR4## is a nitrogen containing ring, ##STR5## must be phenyl; Z is an alkylene chain having 0 to 2 carbon atoms in the chain, said 2 carbon chain optionally having one double bond, said chain optionally having either a carbonyl oxygen, or a hydroxy group as a substituent; W is ##STR6## wherein p is 1 or 2 and n is 1 or 2, R.sup.1 is C.sub.1 to C.sub.6 alkyl, R.sup.2 is hydrogen or C.sub.1 to C.sub.6 alkyl, and the dotted line represents an optional double bond, R.sup.2 being absent if the double bond is present, and Y is substiuted carboxylate or substituted sulfonyl. Said antihistamines have little or no sedative effects.

REFERENCES:
patent: 3326924 (1967-06-01), Villani
patent: 3997557 (1976-12-01), Helsley et al.
Chemical Abstracts, 72:90465u, (1970).
Chemical Abstracts, 82:51351r, (1975).
Chemical Abstracts, 82:125317h, (1975).
Chemical Abstracts, 69:18890z, (1968).
Chemical Abstracts, 82:16734w, (1975).
Chemical Abstracts, 82:140188k, (1975).
Chemical Abstracts, 94:47058f, (1981).
Cram, D., et al., Organic Chemistry, McGraw Hill, New York, 1959, p. 487.

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