Preparation of 1-benzylazetidin-3-ol

Details Preparation of 1-benzylazetidin-3-ol Preparation of 1-benzylazetidin-3-ol

1984-04-27

1985-12-24

Daus, Donald G.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07D20504

Patent

active

045605076

ABSTRACT:
1-Benzylazetidin-3-ol, a precursor to 3-carboxyazetidine, is prepared by heating N-benzyl-3-amino-1-chloropropan-2-ol in an aqueous medium, optionally treating the resulting hydrochloride salt with an alkali metal base.

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Gaertner, Tetrahedron Letters, No. 39, 1966, pp. 4691-4694.
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Mannich, et al., Ber., 70, (1937), pp. 210-213.
Ross, et al., J. Org. Chem., 29, (1964), pp. 824-826.
Nakagawa, et al., Chem. Abstracts, vol. 88, (1978) Abst. #62304c and vol. 82 (1975) #125293x.

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