Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1989-02-27
1992-03-17
Moskowitz, Margaret
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
424530, 514 8, 514 12, 514 21, 530381, A61K 3514, C07K 1500
Patent
active
050970186
ABSTRACT:
Factor VIII concentrate, or Factor IX concentrate, or fibrinogen concentrate, or other clotting-factor product, is subjected to a sequence of heating steps to reduce the infectivity of a virus (such as hepatitis- or AIDS-causing virus), if present. The heating is performed while the concentrate is lyophilized (or dried by another process). The heating steps in the sequence are for two or more different times, and at two or more different temperatures. After the heating sequence, the concentrate is reconstituted for use. This sequential method contemplates greater inactivation of different viral forms, or reduction of the heating required, or both. Reduction of heating requirements may appear as reduced overall heating time, or reduced aggregate power consumption, or both. Advantages include heightened quality-control assurance level. Also possibly, the invention offers some potential for preparation of vaccines against the virus, if sufficient quantity of the virus is present in the concentrate.
REFERENCES:
patent: 4456590 (1984-06-01), Rubinstein
patent: 4556558 (1985-12-01), Rubinstein
Baker R. Keith
Epstein Natan
Moskowitz Margaret
University of Southern California
LandOfFree
Sequential heat treatment of blood-clotting factor products does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Sequential heat treatment of blood-clotting factor products, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Sequential heat treatment of blood-clotting factor products will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1476935