Peptides related to somatostatin

Details Peptides related to somatostatin Peptides related to somatostatin

1978-11-20

1980-04-22

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424177, C07C10352, A61K 3700

Patent

active

041995015

ABSTRACT:
Tetradecapeptides of the formula ##STR1## wherein X is H-Ala-D-Ala, H-D-Ala-Gly, or H-D-Val-Gly, and X.sup.1 is Phe or Cha, or a non-toxic pharmaceutically acceptable acid addition salt thereof, inhibit the secretion of growth hormone without materially inhibiting the secretion of glucagon or insulin. Intermediates and processes for making the tetradecapeptides are also described.

REFERENCES:
patent: 3904594 (1975-09-01), Guillemin et al.
patent: 4061607 (1977-12-01), Shields
patent: 4061626 (1977-12-01), Shields
patent: 4062816 (1977-12-01), Shields
patent: 4076659 (1978-02-01), Shields
patent: 4077952 (1978-03-01), Sarantakis
patent: 4087390 (1978-05-01), Shields
patent: 4100117 (1978-07-01), Shields
patent: 4123425 (1978-10-01), Garsky
Rivier et al., Peptides 1976, 427-451.

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