Method of making a diastereomeric mixture containing two diaster

Details Method of making a diastereomeric mixture containing two diaster Method of making a diastereomeric mixture containing two diaster

1985-10-29

1988-01-26

Brust, Joseph Paul

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

548344, 548497, 548533, 548535, 560 16, 560 40, 560153, 560169, 560170, 560171, 562443, 562445, 562446, 562493, 562557, 562559, 562561, 562563, 562567, 562571, 562573, 562575, 562590, 562607, C07C10346, C07D20716

Patent

active

047218037

ABSTRACT:
In the process of hydrocarboxylating an .alpha.-enamide with CO and an organic hydroxyl compound to produce a N-acyl-.alpha.-amino acid ester, the improvement comprising using as the organic hydroxyl compound reactant, an organic hydroxyl compound which has a chiral center that is essentially all L or D, thereby producing a reaction mixture having essentially no enantiomeric pairs and containing diastereomeric N-acyl-.alpha.-amino acid esters having two chiral centers.

REFERENCES:
Becker et al.; J. Org. Chem., 45 (1980), pp. 2145-2151.
Barton; "Protective Groups in Organic Chemistry" (McOmie, Ed.), Plenum Press, London (1973), pp. 46-49.

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