1-(Substituted-aminoalkoxyphenyl)-2-methylene-1-alkanones, compo

Details 1-(Substituted-aminoalkoxyphenyl)-2-methylene-1-alkanones, compo 1-(Substituted-aminoalkoxyphenyl)-2-methylene-1-alkanones, compo

1978-11-16

1982-08-03

Ramsuer, Robert W.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

42424858, 424263, 424267, 424274, 544174, 546340, 2603265J, 26050121, 564353, 564354, 424316, A61K 31135, C07C 9710

Patent

active

043427820

ABSTRACT:
1-(Substituted-aminoalkoxyphenyl)-2-methylene-1-alkanones, a class of compounds possessing antiallergic propertiesfor use in the treatment of allergic conditions, such as asthma prepared by etherifying an alkanoylphenol with an aminoalkyl halide, converting the ether formed to a salt of Mannich base by reacting it with a salt of a secondary amine in the presence of formaldehyde or paraformaldehyde and treating the Mannich salt with a weak base todeaminate the same and form the final product.

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patent: 3538154 (1970-11-01), Cragoe, Jr. et al.
patent: 3855296 (1974-12-01), Griot
patent: 3919327 (1975-11-01), Lednicer
Fisons Corporation Technical Bulletin, "Intal", No. (02-0670-60-3), Jul. 1974.
Fed. Proc. 36 (3), 5014 (1977).

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