Bis-esters of 1,1-alkanediols with 6-beta-hydroxymethylpenicilla

Details Bis-esters of 1,1-alkanediols with 6-beta-hydroxymethylpenicilla Bis-esters of 1,1-alkanediols with 6-beta-hydroxymethylpenicilla

1981-03-23

1982-08-03

Trousof, Natalie

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

2602391, 424226, 424271, A61K 31495, C07D49974, C07D49976

Patent

active

043427685

ABSTRACT:
Bis-Esters of 1,1-alkanediols with 6-beta(hydroxymethyl)penicillanic acid 1,1-dioxide and 6-betaacylaminopenicillanic acids are useful as antibacterial agents. Intermediates useful for the preparation of these compounds include halomethyl, alkylsulfonyloxymethyl and arylsulfonyloxymethylesters of 6-beta(hydroxymethyl)penicillanic acid 1,1-dioxide and 6-beta-aminopenicillanoyloxymethyl-6-'-beta-(hydroxymethyl)-penicillanate 1,1-dioxide.

REFERENCES:
patent: 4244951 (1981-01-01), Bigham

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