Detection of schistosomiasis antibodies

Details Detection of schistosomiasis antibodies Detection of schistosomiasis antibodies

1992-10-13

1995-01-24

Bidwell, Carol E.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 792, 435 794, 435970, 436531, 436811, G01N 33569

Patent

active

053842448

ABSTRACT:
The present disclosure is directed to a peptide having active binding sites in a protein wherein the binding sites attract and hold antibodies for schistosomiasis in humans. A test reagent is set forth. Separate binding sites in the complex protein have been identified, and the binding sites in such reagent define the mechanism whereby the antibodies in the human serum provide a test reaction.

REFERENCES:
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patent: 4554101 (1985-11-01), Hopp et al.
Chappell et al., "Cloned Schistosoma mansoni Proteinase (Hemoglobinase) as a Putative Sevodiagnostic Reagent", J. Clin. Microbiol., 27(1):196-198 (Jan. 1989).
Davis et al. "Cloning and Gene Expression of Schistosoma mansoni: Protease", J. Biol. Chem., 262(26):12851-12855 (Sep. 15, 1987).
Voller et al. "Enzyme-Linked Immunosorbent Assay" in Manual of Clinical Laboratory Immunology, pp. 99-109 (1986). American Society for Microbiology (Washington D.C.).
Hopp et al. "A Computer Program for Predicting Protein Antigenic Determinants", Molecular Immunology, 20(4):483-489 (1983).
Bangs, Uniform Latex Particles, Seradyn, Inc. (Indianapolis, Ind.), pp. 11-16 (1984).
Klinkert et al. "Expression of diagnostic 31/32 Kilodalton proteins of Schistosoma mansoni as fusions with bacteriophaga MS2 polymerase", Mol. Biochem. Parasit., 27(2-3):233-240 (Jan. 15, 1988).
Klinkert et al. "Primary structures of Sm 31/32 diagnostic proteins of Schistosoma mansoni and their identification as proteases", Mol. Biochem. Parasit., 33(2):113-122 (Mar. 1, 1989).

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