Derivatives of 4-(arylpiperazinyl-ethylaminoethoxy) phenol usefu

Details Derivatives of 4-(arylpiperazinyl-ethylaminoethoxy) phenol usefu Derivatives of 4-(arylpiperazinyl-ethylaminoethoxy) phenol usefu

1985-08-07

1988-01-26

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544360, 544394, A61K 31495, C07D24104, C07D40104

Patent

active

047217154

ABSTRACT:
Compounds of the formula (I): ##STR1## wherein n is 0 or 1, R.sub.1 is H or a lower alkyl of 1 to 6 carbon atoms, R.sub.2 is an unsubstituted phenyl group or a phenyl group substituted by one or more of the same or different substituents selected from the group consisting of hydroxy, lower alkyl of 1 to 6 carbon atoms, lower alkoxy of 1 to 6 carbon atoms, chloro, fluoro, trifluoromethyl or a 2-, 3- or 4- pyridyl ring, in the form of a free base or a pharmaceutically acceptable acid addition salt thereof.
The compounds of the present invention are useful in cardiovascular, antiallergy, psychotropic and hypolipidemic therapy.

REFERENCES:
patent: 3701777 (1972-10-01), Edenhofer et al.
patent: 3951983 (1976-04-01), Danilewicz et al.
patent: 4252804 (1981-02-01), Joullie et al.
J. Med. Chem., R. Ratouis et al (Mar. 1965), pp. 271-273, Synthesis and Pharmacological Study of New Piperazine Derivatives, III. Phenoxyalkylpiperazines.
Chimie Therapeutique, L. Cronenberger et al. (1966), pp. 289-291, Synthese de Nouvelles N-(Aryloxyalkyl)-Piperazines(').

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