Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1999-02-23
2000-01-11
Elliott, George C.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 231, 536 243, 536 2433, 435 6, 435 911, C07H 2104, A61K 4800, C12N 1511, C12Q 168
Patent
active
060137878
ABSTRACT:
Antisense compounds, compositions and methods are provided for modulating the expression of Smad4. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Smad4. Methods of using these compounds for modulation of Smad4 expression and for treatment of diseases associated with expression of Smad4 are provided.
REFERENCES:
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Kretzschmar et al., SMADs: mediators and regulators of TGF-beta signaling, Curr. Opin. Genet. Dev., 1998, 8:103-111.
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Cowsert Lex M.
Monia Brett P.
Elliott George C.
Epps Janet
Isis Pharmaceuticals , Inc.
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