Derivatives of 3-nitropyridines useful as adjuncts to radiation

Details Derivatives of 3-nitropyridines useful as adjuncts to radiation Derivatives of 3-nitropyridines useful as adjuncts to radiation

1988-11-17

1990-01-09

Fan, Jane T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D21376

Patent

active

048929514

ABSTRACT:
Substituted 3-nitropyridines are disclosed to have activity in increasing the sensitivity of hypoxic tumor cells to therapeutic radiation. Also disclosed are methods of preparing such compounds by amination of the corresponding chloro-3-nitropyridine with 2,3-dihydroxypropylamine and pharmaceutical compositions including such compounds.

REFERENCES:
patent: 4443458 (1984-04-01), Hartman
patent: 4609659 (1986-09-01), Hartman
Olive, P. L. Cancer Research 39 pp. 4512-4515 (Nov. 1979).
Israel, M. et al. J. Med. Chem. (1973) vol. 6 No. 5 pp. 520-524.

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