Derivatives of 3-nitropyridines useful as adjuncts to radiation

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

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C07D21376

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active

048929514

ABSTRACT:
Substituted 3-nitropyridines are disclosed to have activity in increasing the sensitivity of hypoxic tumor cells to therapeutic radiation. Also disclosed are methods of preparing such compounds by amination of the corresponding chloro-3-nitropyridine with 2,3-dihydroxypropylamine and pharmaceutical compositions including such compounds.

REFERENCES:
patent: 4443458 (1984-04-01), Hartman
patent: 4609659 (1986-09-01), Hartman
Olive, P. L. Cancer Research 39 pp. 4512-4515 (Nov. 1979).
Israel, M. et al. J. Med. Chem. (1973) vol. 6 No. 5 pp. 520-524.

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