Dimeric fluorescent energy transfer dyes comprising asymmetric c

Details Dimeric fluorescent energy transfer dyes comprising asymmetric c Dimeric fluorescent energy transfer dyes comprising asymmetric c

1995-07-12

1998-06-02

Campbell, Eggerton A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 6, C07H 2102, C12Q 168

Patent

active

057602018

ABSTRACT:
Novel fluorescent heterodimeric DNA-staining energy transfer dyes are provided combining asymmetric cyanine azole-indolenine dyes, which provide for strong DNA affinity, large Stokes shifts and emission in the red region of the spectrum. The dyes find particular application in gel electrophoresis and for labels which may be bound to a variety of compositions in a variety of contexts. Kits and individual compounds are provided, where the kits find use for simultaneous detection of a variety of moieties, particularly using a single narrow wavelength irradiation source. The individual compounds are characterized by high donor quenching and high affinity to dsDNA as a result of optimizing the length of the linking group separating the two chromophores.

REFERENCES:
patent: 5312921 (1994-05-01), Glazer et al.
patent: 5565554 (1996-10-01), Glazer et al.
Hamer, "The Cyanine Dyes in Related Compounds", The Chemistry of Heterocyclic Compounds (1964), 18:210-239 (Interscience Publisher, New York).
Ernst et al., Cytometry (1989), 10:3-10.
Benson et al., Nucleic Acids Research (1993), 21:5720-5726.

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