Potent penetration enhancers

Details Potent penetration enhancers Potent penetration enhancers

1996-10-18

1998-06-02

MacMillan, Keith

Drug, bio-affecting and body treating compositions

Penetrant or absorbent

514947, A61K 3702

Patent

active

057600961

ABSTRACT:
The epidermal permeability barrier to systemically and/or topically active agents or compositions designed for topical administration is enhanced to an unexpected degree by certain combinations of known penetration enhancing excipients. One group of combinations comprise a glycol and an alcohol at a weight ratio within the range of 1:0.1 to 1:10 with one or more further additives, selected from the excipient groups of branched-chain esters of fatty acids, surfactants, and membrane fluidizers. Another group of combinations comprise an alcohol of four or more carbon atoms and one or more further additives selected from the excipient groups of glycols and surfactants.

REFERENCES:
patent: 5238993 (1993-08-01), Catz et al.
patent: 5614178 (1997-03-01), Bloom et al.

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