Arylhydrazone derivatives useful as antibacterial agents

Details Arylhydrazone derivatives useful as antibacterial agents Arylhydrazone derivatives useful as antibacterial agents

1996-09-13

1998-06-02

Reamer, James H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514443, 514523, 514639, 546286, 546287, 546288, 546289, 546290, 546291, 546292, 546293, 546296, 546297, 546329, 546330, 546332, 549 57, 552 8, A01N 3734

Patent

active

057600635

ABSTRACT:
The subject invention, provides arylhydrazone compounds having the Formula 1: ##STR1## wherein A and B are independently aryl or heteroaryl and A and B independently are substituted with at least one group selected from alkyl, halogen, CN, COOR.sup.7, NR.sup.7 R.sup.8, CONR.sup.7 R.sup.8, NO.sub.2, SR.sup.7, SOR.sup.7, SO.sub.2 R.sup.7, NHCOR.sup.7, NHSO.sub.2 R.sup.7, OR.sup.7, hydroxyalkyl, and aminoalkyl. The compounds of this invention are useful for treating a wide variety of bacterial infections, including diseases of the skin, e.g., acne and skin ulcers, gastroenteritis, colitis, meningitis, keratinitis, conjunctivitis, diseases of the urinary and genital tracts, etc.

REFERENCES:
patent: 2658889 (1953-11-01), Goldberg et al.
patent: 3157569 (1964-11-01), Addor et al.
patent: 3839564 (1974-10-01), Wright et al.
patent: 4830957 (1989-05-01), Sato et al.
patent: 4837142 (1989-06-01), Sato et al.
Hassaneen et al., Heterocycles, 36(8):1775-1781, 1993.

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