Peptides useful for altering .alpha..sub.v .beta..sub.3 -mediate

Details Peptides useful for altering .alpha..sub.v .beta..sub.3 -mediate Peptides useful for altering .alpha..sub.v .beta..sub.3 -mediate

1995-04-12

1998-06-02

Russel, Jeffrey E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 12, 514 13, 514 14, 514 15, 514 16, 514 17, 530317, 530324, 530325, 530326, 530327, 530328, 530329, A61K 3808, A61K 3810, A61K 3812, A61K 3816

Patent

active

057599963

ABSTRACT:
The present invention provides Arg-Gly-Asp peptides that can alter the binding of osteoclasts to a matrix such as bone or can selectively alter integrin receptor binding. The invention also provides methods of using the Arg-Gly-Asp peptides to alter .alpha..sub.v .beta..sub.3 integrin receptor-mediated binding of a cell such as an osteoclast, endothelial cell or smooth muscle cell to a matrix. The invention further provides methods for ameliorating the severity of a pathology characterized, in part, by an undesirable level of bone resorption, angiogenesis or restenosis in a subject.

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Matsuno, Hiroyuki. et al., "Inhibition of Integrin Function by a Cyclic RGD-Containing Peptide Prevents Neointima Formation." Circulation 90:2203-2206 (1994).
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PCT Search Report (dated 9 Nov. 1995), International application No. PCT/US95/04741.

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