Lipid derivatives, their production and use

Details Lipid derivatives, their production and use Lipid derivatives, their production and use

1990-07-23

1991-06-18

Shippen, Michael L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514210, 514211, 514212, 5142222, 5142375, 514255, 514256, 514326, 514341, 514342, 514348, 514357, 514417, 514418, 540544, 540553, 540608, 544 59, 544158, 544159, 544160, 544161, 544168, 544171, 544310, 544312, 544336, 544389, 544400, 546226, 546244, 546247, 546272, 546276, 546278, 546332, 546334, 546335, 548181, 548309, 548341, 548312, 548465, 548477, 548538, 548567, 548953, 548966, A61K 3133

Patent

active

050250051

ABSTRACT:
Novel lipid derivatives of the formula ##STR1## [wherein R.sup.1 is alkyl or alkylcarbamoyl; R.sup.2 is hydrogen, hydroxy which may be substituted, amino which may be substituted or cyclic amino; R.sup.3 is a chemical binding or alkylene which may be substituted; R.sup.4 is hydrogen, alkyl or aralkyl; X and Y are independently O, S or an imino group which may be substituted, and when Y is an imino group, Y, together with the imino group represented by X or R.sup.4, may form a ring; and Z is imino or a nitrogen-containing heterocyclic ring which may be substituted] and salts thereof have inhibiting activity on platelet activating factor and are useful as a preventive or therapeutic agent for a variety of circulatory diseases and allergic disorders and also as an antineoplastic agent.

REFERENCES:
patent: 4408052 (1983-10-01), Hozumi et al.
patent: 4426525 (1984-01-01), Hozumi et al.
patent: 4582824 (1986-04-01), Nishikawa et al.
patent: 4731373 (1988-03-01), Barner
Central Patents Index Basic Abstracts Journal Section B: Week K14 (1 Jun. 83) 33708 K/14 J58035-116.

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