Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Albumin
Patent
1994-12-08
1998-12-15
Fleisher, Mindy
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Albumin
530363, 530413, 530416, 530417, C07K 14765, C07K 118, C07K 122, C07K 136
Patent
active
058498745
ABSTRACT:
Recombinantly produced serum albumin is purified in a series of steps, optionally by incubation with an anion-exchange adsorbent, followed by affinity chromatography employing a hydrophobic solid phase and using a water-soluble lipid anion as desorbens in the aqueous phase. This immobile phase comprises a carrier coupled to a 2-mercapto or 2-hydroxy alkanoic acid.
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Wilchek et al., "Affinity Cromatography", Methods in Enzymology (1984) 104:3.
Stoltz et al., "A Pilot Scale Chromatographic Purification of Albumin From Human Plasma", Bio-Sciences (1987) 6:(4):103-106.
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Wichman et al. Biochim et Biophys Acta 372 218-224 1974.
White et al. "Principles of Biochemistry" p. 581 1978.
Harris et al. "Protein Purification Methods" pp. 245-246, 262 1989.
Scouten "Affinity Chromatography: Bioselective Adsorption on Inert Mahlies" pp. 48-49 1981.
Piet Marcellinus Petrus Johannes
Van Der Laken Cornelis Jacobus
Degen Nancy J.
Fleisher Mindy
Gist-brocades, N.V.
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