Prostaglandin derivatives for the treatment of glaucoma or ocula

Details Prostaglandin derivatives for the treatment of glaucoma or ocula Prostaglandin derivatives for the treatment of glaucoma or ocula

1995-06-05

1998-12-15

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

A61K 31557

Patent

active

058497919

ABSTRACT:
The invention relates to ophthalmological compositions for topical treatment of glaucoma or ocular hypertension comprising an effective intraocular pressure reducing amount of a prostaglandin derivative of PGA, PGB, PGD, PGE or PGF, in which the omega chain contains a ring structure, in an ophthalmologically compatible carrier. The invention further relates to the preparation of said compositions and their use for treatment of glaucoma or ocular hypertension.

REFERENCES:
patent: 3956284 (1976-05-01), Hess et al.
patent: 3962312 (1976-06-01), Hayashi et al.
patent: 3987087 (1976-10-01), Bundy
patent: 4001300 (1977-01-01), Axen
patent: 4011262 (1977-03-01), Hess et al.
patent: 4061865 (1977-12-01), Hatashi et al.
patent: 4115586 (1978-09-01), Miller, Jr.
patent: 4116988 (1978-09-01), Nelson
patent: 4117119 (1978-09-01), Kurono et al.
patent: 4128713 (1978-12-01), Schneider
patent: 4131738 (1978-12-01), Smith
patent: 4599353 (1986-07-01), Bito
patent: 4820728 (1989-04-01), Collins et al.
patent: 4824857 (1989-04-01), Goh et al.
patent: 4883819 (1989-11-01), Bito
patent: 5001153 (1991-03-01), Ueno et al.
patent: 5057621 (1991-10-01), Cooper et al.
patent: 5151444 (1992-09-01), Ueno et al.
patent: 5166178 (1992-11-01), Ueno
patent: 5194429 (1993-03-01), Ueno
Bill A (1975) "Blood Circulation and fluid dynamics in the eye". Physiol. Rew. 55: 383-417.
Bito LZ, Draga A, Blanco DJ, Camras CB (1983) "Long Term Maintenzance of Reduced intraocular Pressure by Daily or Twice Daily Topical Application of Prostaglandins to Cat or Rhesus Monkey Eyes" Invest. Ophthalmol. Vis. Sci. 24: 312-319.
Bito, Baroody and Miranda (1987): Eicosanoids as a new class of ocular Hypotensive agents. The apparent therapeutic advantage of derived Prostaglandins of the A and B type as compared with primary prostaglandins of the E, F and D types, Experimental Eye Research, 44:825.
Bito LZ, Camras CB, Gum GG and Resul B (1989). "The Ocular Hypotensive Effects and Side Effects of Prostaglandins on the Eyes of Experimental Animals" Progress in Clinical and Biological Research 312 Ed. LZ Bito and Johan Stjernschantz, A.R. Liss, Inc., New York.
Burke et l., Prostaglandin F.sub.2.alpha. Effects on Rabbit IOP Negatively Correlate with Classical PGF.sub.2.alpha. -Receptor Stimulation Presented at ARVO annual meeting in Florida May 1-6, 1988.
Bundy, Chem Abst. 90:168141d, 1979.
Camras CB, Bito LZ (1981). Reduction of intraocular pressure in normal and glaucomatous primate (Aotus trivirgatus) eyes by topically applied prostaglandin F.sub.2a. Curr Eye Res 1:205-209.
Camras, CB, Podos SM, Rosenthal JS, Lee PY, Severin CH (1987a). Multiple dosing of prostaglandin F.sub.2a or epinephrine on cynomolgus monkey eyes. I. Aqueous humor dynamics. Invest Ophthalmol Vis Sci 28:463-469.
Camras C B, Bito L Z and Eakins K E (1977): "Reduction of intraocular pressure by prostaglandins applied to the eyes of concious rabbits", Invest Ophthalmol Vis. Sci, 16:1125.
Camras CB, Bhuyan KC, Podos SM, Bhuyan DK Master RWP (1987b) "Multiple Dosing of Prostaglandin F.sub.2.alpha. or epinephrine on cynomologus monkey eyes. II. Slitlamp biomicroscopy, aqueous humor analysis, and fluorescein angiography." Invest. Ophthalmol. Vis. Sci. 28: 921-926.
Camras CB, Siebold EC, Lustgarten JS, Serle JB, Frisch SC, Podos SM, Bito LZ (1988) "Reduction of IOP by prostaglandin F.sub.2.alpha. -1 isopropyl ester topically applied in glaucoma patients", Ophthalmology 95(Supply.) 129.
Crawford K, Kaufman PL and True Gabel, BA (1987), "Pilocarpine antagonizes PGF.sub.2.alpha. -induced ocular hypotension: Evidence for enhancement of uveoscleral outflow of PGF.sub.2.alpha.." Invest. Ophthalmol. Vis. Sci. (Supp.) ARVO Abstracts 11.
Crawford, K and Kaufman, P.L., (1987) "Pilocarpine Antagonizes Prostaglandin F.sub.2.alpha. -Induced Ocular Hypotension in Monkeys" Arch. Opthamology 105 1112.
Flach AJ, Elisason JA (1988). Topical prostaglandin E.sub.2 effects on normal human intraocular pressure. J. Ocu. Pharmacol. 4:13-18.
Gabelt, B. and Kaufman, P.L., (1989)"Prostaglandin F.sub.2.alpha. Increases Uvelscleral Outflow in the Cynomologus Monkey", Exp. Eye Res. 49 389-402.
Giuffre G. (1985). "The effects of prostaglandin F.sub.2.alpha. in the human eye." Graefes Arch Clin. Exp. Ophthalmol.222:139-141.
Goldberg I, Kolker A.E., Kass M.A. and Becker B (1980) "Dipivefrin: current concepts", Australia J. Ophthalmol., 8:147.
Granstrom, E., (1975) "Metabolism of 17-Pheny-18,19,20-Trinor-Prostaglandin F.sub.2.alpha. in the Cynomolgus Monkey and the Human Female", Prostaglandins 9:19-45.
Kass, M.A., Posos, S.M., Moses, R.A., and Becker B. (1972): Prostaglandin E1 and aqueous humor dynamics, Invest Ophthamol. 11:1022.
Kass M.A., Mandell AL, Goldberg I, Paine J.M. and Becker B (1979) "Dipivefrin and epinephrine treatment of elevated intraocular pressure: A comparative study", Arch Ophthamol. 97:1865.
Kaufman PL (1986). "Effects on intracamerally infused prostaglandins on outflow facility in cynomolgus monkey eyes with intact or retrodisplaced ciliary muscle." Exp. Eye Res. 43:819-827.
Kerstetter J R, Brubaker R F, Wilson S E and Kullerstrand B S (1987): "Prostaglandin F2 alpha 1-isopropyl ester effects on aqueous humor dynamics in human subjects", Invest Ophthalmol Vis Sci Suppl, 28:266.
Kerstetter J R, Brubaker R F, Wilson S E and Kullerstand L (1988) "Prostaglandin F2.alpha.-1-Isopropylester Lowers Intracolor Pressure Without Decreasing Aqueous Humor Flow". Am. J. Ophthamology 105:30-34.
Kirk-Othmar "Encyclopedia of Chemical Technology", 3d Ed. Supplement vol. 711-752 (1984).
Lee, P-Y, Shae H, XZu L, Qu C-K (1988). The effect of prostaglandin F.sub.2.alpha. on intraocular pressure in normotensive human subjects. Invest. Ophthamol. Vis. Sci. 29:1474-1477.
Miller, "Biological Activities of 17-phenyl-18,19,20-trinorprostaglandins", Prostaglandins 9 9-18 (1975).
Nilsson SFE, Stjernschantz J and Bill A (1987) PGF.sub.2.alpha. increase uveoscleral outflow. Invest. Ophthamol Vis. Sci. Suppl. 284.
Ritch, Shields and Krupin (1989): "The Glaucomas", C V Mosby, p. 561.
Starr, M.S. (1971) Further studies on the effect of prostaglandin on intraocular pressure in the rabit, Exp. Eye, Res. 11:170.
Villumsen J, Alm A, Soderstrom M, (1989) "Prostaglandin F2.alpha.-isopropylester Eye Drops: Effect on Intraocular Pressure in Open Angle Glaucoma". Brit. J. Ophthalmology 73, 975-79.
Villumsen J. Alm A (1989) "Prostaglandin F.sub.2.alpha. isopropylester eye drops. Effects in normal human eyes." Br. J. Opthalmol. 73:419-426.
Villumsen J and Alm A (1987): "The effect of prostaglandin F2.alpha. eye drops in open angle glaucoma", Invest Opthalmol. Vis. Sci. 28:378.
Wang R-F, Cmamras C.B., Lee P-Y, Podos S.M. and Bito LZ (1987) The ocular hypotensive effects of Prostaglandins F2.alpha. isopropyl ester and A2 in glautomatous monkeys Invest Ophthalmol Vis Sci ARVO Supl. 28:266.
Yankee, Chem Abst. 88:62048, 1978.
Woodward et al., Prostaglandin F.sub.2.beta. Effects on IOP Negatively Correlate with Classical PGF.sub.2.alpha. -Receptor Stimulation Presented in Eightly International Congress of Eye Research in San Francisco Sep. 4-8, 1988.
Woodward et al. (1989) "Prostaglandin F.sub.2.alpha. Effects on Intraocular Pressure Negatively Correlate with FP-Receptor Stimulation" Invest. Ophthal. 30 (8) 1838-1842.
Supplement to Investigative Ophthalmology and Visual Science 22 39 (1982), L.Z. Bito, A. Draga, J. Blanco and C.B. Camras, "Maintenance of Reduced Intraocular Pressure (IOP) for several months by topical application of prostaglandin (PG) E.sub.1 to Eyes of Trained Cats".
Abstracts 12 and 13 on p. 325 of ARVO Annual Meeting Abstract Issue 1988 of Annual Meeting: Sarasota, Florida May 1-6, 1988.
Abstracts 31,33 and 35 on p. 35 of Abstracts 8th International Congress of Eye Research, San Francisco, Sep. 4-8, 1988.
Journal of Medicinal Chemistry, vol. 23, 1980, pp. 525-535.
Annual Reports in Medicinal Chemistry, vol. 11, 1976, pp. 80-88.
Zajacz: IRCS Medical Science: Clinical Medicine; Clinical Pharmacology and Therapeutics: Drug Metabolism and Toxicology; The Eye: Reproduction, Obstetrics and Gynecology, vol. 4, 197

Affiliated with

Also associated with

Rating

Prostaglandin derivatives for the treatment of glaucoma or ocula does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Prostaglandin derivatives for the treatment of glaucoma or ocula, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Prostaglandin derivatives for the treatment of glaucoma or ocula will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1458479