Assay for determining inhibitors of ATPase

Details Assay for determining inhibitors of ATPase Assay for determining inhibitors of ATPase

1996-03-08

1998-06-02

Gitomer, Ralph

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving hydrolase

435 5, 435 8, 435184, C12Q 142

Patent

active

057597952

ABSTRACT:
This invention provides materials and methods for identifying inhibitors of a Hepatitis C Virus NS3 protein ATPase. Methods for making and purifying such an ATPase are also provided by this invention.

REFERENCES:
patent: 4264727 (1981-04-01), Kolehmainen et al.
patent: 5527669 (1996-06-01), Resnick et al.
patent: 5580718 (1996-12-01), Resnick et al.
Suzich J., Hepatitis C Virus NS3 Protein Polynucleotide Stimulated Nucleoside Triphosphatase and Comparison with the Related Pestivirus and Flavivirus Enzymes, J. of Virology 67(10) 6152-6158, Oct. 1993.
Yamada E., Calcium Binding ATPase Inhibitor Protein of Bovine Hear Mitochondira, Biochemistry 28 9714-9718, 1989.

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