Substituted benzoylguanidines process for their preparation, the

Details Substituted benzoylguanidines process for their preparation, the Substituted benzoylguanidines process for their preparation, the

1997-06-30

1998-12-15

Kumar, Shailendra

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514307, 514309, 514311, 514312, 514345, 514427, 514621, 514622, 546139, 546141, 546152, 546153, 546164, 546290, 546300, 548543, 548563, 5483435, 564169, 564142, A61K 31415, C07D23354, C07C23364, C07C23102

Patent

active

058497757

ABSTRACT:
Benzoylguaridines of the formula I ##STR1## are described in which: R(1), R(2), R(3), R(4), R(5) are as defined in the specification, and pharmaceutically tolerated salts thereof.

REFERENCES:
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patent: 5091394 (1992-02-01), Englert et al.
patent: 5292755 (1994-03-01), Englert et al.
patent: 5364868 (1994-11-01), Englert et al.
"Inhibition of Na.sup.+ /H.sup.+ exchange suppresses nor-adrenaline release and arrhythmias in the ischemic rat heart",Schomig et al., Eur. Heart J., Book of Abstracts, 9(suppl. 1) :167(1988).
"Amiloride: Antiarrhythmic and Electrophysiologic Actions in Patients With Inducible Sustained Ventricular Tachycardia", Duff et al., Circulation, 79(6) :1257-1263 (1989).
English Derwent Abstract of EP-A-0612723, 1994.
English Derwent Abstract of DE-A-4318756, 1971.

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