Assays for factors affecting circularization of DNA, assays for

Details Assays for factors affecting circularization of DNA, assays for Assays for factors affecting circularization of DNA, assays for

1995-04-20

1998-06-02

Degen, Nancy

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

435 6, 4352351, 435325, C12Q 170, C12Q 168, C12N 510, C12N 700

Patent

active

057597685

ABSTRACT:
An assay for factors that affect integration of DNA into target DNA is disclosed. Assays for methods of screening for factors which effect viral DNA circularization either by homologous recombination, end-to-end ligation, or autointegration, are also disclosed. A method for screening for factors which will enhance circularization rather than integration by testing cellular cytoplasmic fluid under conditions which permit circularization in the fluid is also described. Factors which effect integration and circularization are disclosed. Therapeutic methods for retarding viral infection are also described.

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