Method for treating allergic lung disease

Details Method for treating allergic lung disease Method for treating allergic lung disease

1996-10-04

1998-12-15

Saunders, David

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

4241841, 514958, 536 231, A01N 4304, A61K 3170, A61K 3900, C07H 2102

Patent

active

058497196

ABSTRACT:
The invention is directed to a method for treating both the early and late phases of allergic asthma by introducing naked polynucleotides which operatively encode for the asthma-initiating antigen into the host. The antigen-encoding polynucleotides are administered to host tissues which contain a high concentration of antigen presenting cells (e.g., skin and mucosa) relative to other host tissues. Expression of the asthma-initiating antigen encoding polynucleotides of the invention inside of antigen presenting cells (without substantial secretion therefrom) induces antigen tolerance while suppressing IgE antibody formation in the early phase of the disease, and also suppresses cytokine-mediated eosinophil accumulation in the late phase of the disease. Devices and compositions for use in the methods of the invention are also described.

REFERENCES:
patent: 4228795 (1980-10-01), Babington
patent: 5580859 (1996-12-01), Felgner et al.
patent: 5589466 (1996-12-01), Felgner et al.
Manickan, E et al. Critical Reviews in Immunology. 17(2):139-154 Mar. 1997.
Hoyne, GF and Lamb, JR. Immunology and Cell Biology. 74:180-188 Feb. 1986.
Tang, et al.; "Genetic Immunization is a Simple Method for Eliciting an Immune Response"; Nature, vol. 356, Mar. 12, 1992, pp. 152-154.
Stribling, et al.; "Aerosol Gene Deliver in vivo"; Proc. Natl. Acad. Sci. USA; vol. 89, pp. 11277-11281, Dec. 1992; Medical Sciences.

Affiliated with

Also associated with

Rating

Method for treating allergic lung disease does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for treating allergic lung disease, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for treating allergic lung disease will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1457994