Tumor necrosis factor inhibitory protein and its purification

Details Tumor necrosis factor inhibitory protein and its purification Tumor necrosis factor inhibitory protein and its purification

1995-06-07

1999-11-09

Draper, Garnette D.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

530351, 530344, 530395, 514 2, 514 8, 514 12, 424 851, C07K 14705

Patent

active

059817011

ABSTRACT:
Tumor Necrosis Factor (TNF) Inhibitory Protein is isolated and substantially purified. It has the ability to inhibit: (a) the binding of TNF to its receptors, and (b) the cytotoxic effect of TNF. TNF Inhibitory Protein and salts, functional derivatives and active fractions thereof can be used to antagonize the deleterious effects of TNF.

REFERENCES:
patent: 4966888 (1990-10-01), Saxena et al.
patent: 5136021 (1992-08-01), Dembinski et al.
patent: 5344915 (1994-09-01), LeMaire et al.
patent: 5359037 (1994-10-01), Wallach et al.
patent: 5395760 (1995-03-01), Smith et al.
patent: 5447851 (1995-09-01), Beutler et al.
patent: 5478925 (1995-12-01), Wallach et al.
patent: 5512544 (1996-04-01), Wallach et al.
patent: 5605690 (1997-02-01), Jacobs et al.
patent: 5610279 (1997-03-01), Brockhaus et al.
patent: 5672347 (1997-09-01), Aggarwal etal.
Seckinger et al. A Human Inhibitor of Tumor Necrosis Factor alpha. Journal of Experimental Medicine. pp. 1511-1516, Apr. 1988.
Loetsch, H. et al., "Purification and Partial Amino Acid Sequence Analysis of Two Distinct Tumor Necrosis Factor Receptors from HL60 Cells", The Journal of Biological Chemistry, vol. 265, No. 33, pp. 20131-20138, Nov. 25, 1990.
Peetre et al., "A Tumor Necrosis Factor Binding Protein is Present in Human Biological Fluids", Eur. J. Haematol, vol. 41, pp. 414-419, 1988.
Sechinger, et al., "A Human Inhibitor of Tumor Necrosis Factor .alpha.", J. Exp. Med., vol. 167, pp. 1511-1516, Apr. 1988.
Lee, et al., "Generation of cDNA Probes Directed by Amino Acid Sequences", Science, vol. 239, pp. 1288-1291, 1988.
Hass, et al., "Characterization of Specific High Affinity Receptors for Human TNF . . . ", J. of Biol. Chem., vol. 260, pp. 12214-12218, 1985.
Baglioni, et al., "Binding of TNF to High Affinity Receptors on HeLa and Lympheblastoid . . . ", J. of Biol. Chem., vol. 260, pp. 13395-13397, 1985.
Israel, et al., "Binding of Human TNF-.alpha. to High Affinity Cell Surface Receptors . . . ", Immunology Letters, vol. 12, pp. 217-224, 1986.
Niitso, et al., "Receptor Protein for Physiologically Active Substances", JPO Public Disclosure Bulletin, vol. 61, p. 293924, Dec. 24, 1986.
Yoshie, et al., "Binding and Crosslinking of .sup.125 I-Labeled Recombinant Human TNF", J. Biochem., vol. 100, pp. 531-541, 1986.
Suggs, et al., "Use of Synthetic Oligonucleotides as Hybridization Probes", PNAS, vol. 78, pp. 6613-6617, 1981.
Beutler, B. et al., "Passive Immunization Against Cachectin/Tumor Necrosis Factor Protects Mice from Lethal Effect of Endotoxin", Science, vol. 229, pp. 869-871, Aug. 30, 1985.
Creasy, A. A., et al., "A high molecular weight component of the human tumor necrosis factor receptor is associated with cytotoxicity", PNAS, vol. 84, pp. 3293-3297, May 1987.
Kasukabe, T. et al., "Purification of a Novel Growth Inhibitory Factor for Partially Differentiated Myeloid Leukemic Cells", J. Biol. Chem., vol. 263, No. 11, pp. 5431-5435, Apr. 15, 1988.
Le, J., et al., "Biology of Disease: Tumor Necrosis Factor and Interleukin 1: Cytokines with Multiple Overlapping Biological Activities", Lab. Investig., vol. 56, No. 3, pp. 234-248, 1987.
Liao, Z., et al., "Characterization of a Human Interleukin 1 Inhibitor", J. Immunol., vol. 134, No. 6, pp. 3882-3886, Jun. 1985.
Seckinger, P., et al. "A Urine Inhibitor of Interleukin 1 Activity that Blocks Ligand Binding", J. Immunol., vol. 139, No. 5, pp. 1546-1549, Sep. 1, 1987.
Tracey, J. et al., "Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia", Nature, vol. 330, pp. 662-664, Dec. 17, 1987.
Tsujimoto, M., et al., "Characterization and Affinity Crosslinking of Receptors", Archives of Biochem. and Biophysics, vol. 249, No. 2, pp. 563-568, Sep. 1986.
Vitt, C. R., et al., "Biological and Structural Characterization of the Tumor Necrosis Factor Receptor on Multiple Cell Types: Relationship to Function", Fed. Proc., vol. 46, p. 2117, 1987, abstract No. 1118.
Wallach, D., "Preparations of Lymphotoxin Induce Resistance to their Own Cytotoxic Effect", J. Immunol., vol. 132, No. 5, pp. 2464-2469, May 1984.
Walsh, L. J., et al., "Isolation and Purification of ILS, an Interleukin 1 Inhibitor Produced by Human Gingival Epithelial Cells", Clin. Exp. Immunol., vol. 68, pp. 366-374, 1987.
Ulsson et al, Eur. J. Haematol 42, 1989, pp. 270-278.
Engelmann et al JBC 264(20) 1989, pp. 11974-11980.
Seckinger et al JBC 264(20) 1989, pp. 11966-11973.
Engelmann et al, JBC 265(3) 1990, pp. 1531-1536.
Novick et al, J Exp Med 170, 1989, pp. 1409-1414.
Hahmann et al JBC 264(25) 1989, pp. 14927-14934.
Scheurich et al, Int J Cancer 38, 1986, pp. 127-133.
Kull et al, PNAS 82, 1985, pp. 5756-5760.

Affiliated with

Also associated with

Rating

Tumor necrosis factor inhibitory protein and its purification does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Tumor necrosis factor inhibitory protein and its purification, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Tumor necrosis factor inhibitory protein and its purification will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1457620