Novel hmg-coa reductase inhibitors

Details Novel hmg-coa reductase inhibitors Novel hmg-coa reductase inhibitors

1988-12-05

1990-01-09

Pal, Asok

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549292, 514570, C07D30930

Patent

active

048928844

ABSTRACT:
Disclosed are novel 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors useful as antihypercholesterolemic agents represented by the formula ##STR1## and the corresponding ring-opened hydroxy acids derived therefrom and pharmaceutically acceptable salts thereof.
Pharmaceutical compositions containing said compounds and method of inhibiting the biosynthesis of cholesterol therewith are also disclosed.

REFERENCES:
patent: 4567289 (1986-01-01), Willard
patent: 4611067 (1986-09-01), Volante
patent: 4668699 (1987-05-01), Hoffman et al.
patent: 4681893 (1987-07-01), Roth

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