Methods of use of a three-dimensional liver cell and tissue cult

Details Methods of use of a three-dimensional liver cell and tissue cult Methods of use of a three-dimensional liver cell and tissue cult

1996-08-01

1998-12-15

Saucier, Sandra E.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Method of co-culturing cells

435395, 435396, 435397, 435398, 435399, 435402, C12N 500, C12M 300, A61K 200

Patent

active

058495886

ABSTRACT:
The present invention relates to a three-dimensional cell and tissue culture system. In particular, it relates to this culture system for the long term culture of liver cells and tissues in vitro in an environment that more closely approximates that found in vivo. The culture system described herein provides for proliferation and appropriate liver cell maturation to form structures analogous to tissue counterparts in vivo. The resulting liver tissues survive for prolonged periods, perform liver-specific functions, and maintain hepatic tissue architecture following in vivo implantation.
The liver cultures have a variety of applications ranging from transplantation or implantation in vivo, to screening cytotoxic compounds and pharmaceutical compounds in vitro, to the production of biologically active molecules in "bioreactors" and to the construction of extracorporeal liver assist device.

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