Nucleic acid encoding a NF-.kappa.B activation regulatory protei

Details Nucleic acid encoding a NF-.kappa.B activation regulatory protei Nucleic acid encoding a NF-.kappa.B activation regulatory protei

1996-11-13

1998-12-15

Elliott, George G.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

435243, 4353201, 536 235, C12N 510, C12N 100, C12N 1512, C12N 1563

Patent

active

058495800

ABSTRACT:
The present invention provides a novel polypeptide, I.kappa.B-.beta., which binds to and affects NF-.kappa.B gene activation. Also provided is the nucleotide sequence encoding I.kappa.B-.beta. and methods of identifying compositions which affect I.kappa.B-.beta./NF-.kappa.B complexes. Methods of treatment of disorders associated with NF-.kappa.B induced gene activation are also described herein.

REFERENCES:
Link et al, The Journal of Biological Chemistry, Jan. 5, 1992, vol. 267(1): pp. 239-246.
Zabel et al, Cell, Apr. 20, 1990, vol. 61: pp. 255-265.

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