Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1998-08-13
1999-11-09
Achutamurthy, Ponnathapu
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435195, 4352523, 536 232, C12P 2104, C12N 914, C12N 120, C07H 2104
Patent
active
059812320
ABSTRACT:
The present invention provides a human pyrophosphatase (HPYP) and polynucleotides which identify and encode HPYP. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HPYP and a method for producing HPYP. The invention also provides for use of HPYP and agonists, antibodies, or antagonists specifically binding HPYP, in the prevention and treatment of cancer and inflammatory diseases. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HPYP for the treatment of diseases associated with the expression of HPYP. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HPYP.
REFERENCES:
Yang, Z., et al., "Inorganic Pyrophosphatase from Bovine Retinal Rod Outer Segments" J. Biol. Chem., 267:24634-40 (1992).
Yang, Z., et al., "Molecular Cloning and Functional Expression of cDNA Encoding a Mammalian Inorganic Pyrophosphatase" J. Biol. Chem., 267: 24641-47 (1992).
Lacroix, J., et al., (GI 727225), GenBank Sequence Database (Accession 727225), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland 20894.
Kolakowski, L.F., et al., "Cloning, molecular characterization and chromosome localization of the inorganic pyrophosphatase (PPa) gene from S. cerevisiae" Nuc. Acids Re., 16: 10441-52 (1988).
Hawkins Phillip R.
Hillman Jennifer L.
Achutamurthy Ponnathapu
Inctye Pharmaceuticals, Inc.
Slobodyansky Elizabeth
LandOfFree
Human pyrophosphatase does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Human pyrophosphatase, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human pyrophosphatase will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1454282