Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1997-03-26
1999-11-09
Wax, Robert A.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
536 231, 536 234, 536 235, 4352523, 4353201, 530350, C12P 2106, C07H 2102, C07H 2104, C07K 100
Patent
active
059812214
ABSTRACT:
The present invention provides a human histone fusion protein (HFP) and polynucleotides which identify and encode HFP. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. In addition, the invention also provides methods for producing HFP and for treating or preventing disorders associated with expression of HFP.
REFERENCES:
Constaniz, C. And Pehrson, J.R. (GI 1711126), GenBank Sequence Database (Accession U79139), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland 20894.
Goldknopf, I.L., et al., "Isopeptide linkage between nonhistone and histone 2A polypep tides of chromosomal conjugate-protein A24", Proc Natl Acad Sci USA, 74(3): 864-868 (1977).
Palmer, D.K., et al., "Purification of the centromere-specific protein CENP-A and demonstration that it is a distinctive histone", Proc Natl Acad Sci USA, 88(9): 3734-3738 (1991).
Pehrson, J.R., et al., "MacroH2A, a Core Histone Containing a Large Nonhistone Region", Science, 257: 1398-1400 (1992).
Pehrson, J.R., et al., (GI 205275) GenBank Sequence Database (Accession M99065) National Center for Biotechnology Information: National Library of Medicine, Bethesda, Maryland 20849 (205276).
Dobner, T., et al., "A novel divergently transcribed human histone H2A/H2B gene pair", DNA Seq, 1(6): 409-413 (1991).
Pehrson et al. (1992). Science 257: 1398-1400, Sep. 4, 1992.
Goli Surya K.
Hillman Jennifer L.
Incyte Pharmaceuticals Inc.
Mohan-Peterson Sheela
Saidha Tekchand
Wax Robert A.
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