Methods and compositions relating to useful antigens of moraxell

Details Methods and compositions relating to useful antigens of moraxell Methods and compositions relating to useful antigens of moraxell

1995-05-25

1999-11-09

Housel, James C.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 693, 4352522, 4353201, 536 231, 536 237, 536 2432, 4242341, 4242511, C12P 2106, C12N 112, C12N 1500, C07H 2102

Patent

active

059812133

ABSTRACT:
The present disclosure relates to Moraxella catarrhalis outer membrane vesicle (OMV) compositions, to selected antigenic proteins from the outer membranes of M. catarrhalis which have a variety of useful properties, and to monoclonal antibodies against these proteins. Particular "Outer Membrane Proteins" (OMPs) of the invention are characterized as having molecular weights of about 30 kD, 80 kD (also termed CopB protein) and between about 200 and 700 kD (HMWP antigen). Passive immunization with monoclonal antibodies directed against these proteins confers protection against homologous and heterologous Moraxella catarrhalis strains in animal models, and active immunization with outer membrane vesicles also enhances pulmonary clearance of distinct M. catarrhalis strains. This demonstrates both the utility of antibodies in conferring passive immunity and the usefulness of OMPs, or variants thereof, in the preparation of vaccines. Also disclosed are DNA segments encoding these OMPs, methods for preparing the antigens, or variants, through the application of recombinant DNA techniques, as well as diagnostic methods and related embodiments.

REFERENCES:
patent: 5328985 (1994-07-01), Sano et al.
Scripture et al. 1983. J. Biol. Chem. 258(18) :10853-10855.
Barker et al. 1982. Eur. J. Biochem. 127: 449-457.
Rotman et al. 1982. J. Biol. Chem. 257 (15) : 9030-9034.
Marrs et al. May 1990. Am J. Med. 88 (5A), pp. 365-405.

Affiliated with

Also associated with

Rating

Methods and compositions relating to useful antigens of moraxell does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods and compositions relating to useful antigens of moraxell, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and compositions relating to useful antigens of moraxell will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1454158