Surface-enhanced raman medical probes and system for disease dia

Details Surface-enhanced raman medical probes and system for disease dia Surface-enhanced raman medical probes and system for disease dia

1997-09-15

1999-01-26

Hantis, K. P.

Optics: measuring and testing

By dispersed light spectroscopy

With raman type light scattering

G01J 344

Patent

active

058643974

ABSTRACT:
A probe for a surface-enhanced Raman scattering spectrometer includes a member of optically transmissive material for receiving the excitation radiation from a laser and for carrying the radiation emitted from a specimen to a detector. An end of the member for placing against the specimen has a coating that produces surface enhancement of the specimen during Raman scattering spectroscopic analysis. Specifically the coating is formed by a first layer of microparticles on the member and a metal layer over the first layer. The first layer may form a microstructure surface over which a metal layer is applied. Alternatively the coating may be a material containing microparticles of a metal. An optional layer of a material may be applied to the metal layer to concentrate onto the probe compounds of analytical interest onto the probe.

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